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高攝取量腦靶向O-去甲基文拉法辛前體藥物的研究與開發(fā)

成果領(lǐng)域: 精準(zhǔn)醫(yī)療

推廣方式:

成果歸屬企業(yè): 吉林大學(xué)生命科學(xué)學(xué)院顧景凱教授科研團(tuán)隊

成果鑒定時間:

成果介紹

抗抑郁是中樞疾病治療領(lǐng)域最為關(guān)注的問題。基于抗抑郁藥O-去甲基文拉法辛（ODV）腦攝取不足的缺陷，項目團(tuán)隊對其進(jìn)行了結(jié)構(gòu)設(shè)計與優(yōu)化，開發(fā)了ODV酚酯類前體藥物。該前體藥物口服吸收良好、入血后快速透過血腦屏障，在腦組織代謝轉(zhuǎn)化為母體藥物ODV發(fā)揮作用，藥效學(xué)研究其抗抑郁效果可與ODV媲美，但給藥劑量大為降低，臨床應(yīng)用前景廣闊，未來可期。

成果應(yīng)用案例介紹

聯(lián)系方式

電話/微信: 13822630888

相關(guān)成果

免責(zé)聲明 / 網(wǎng)站地圖 / 平臺簡介 / 友情鏈接

郵箱：zeccea@qq.com QQ群：318441538 客服電話：0758-2721389 秘書處電話/微信：13822630888

基本文件流程錯誤 SQL 調(diào)試

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[ BEHAVIOR ] Run Closure @app_init [ RunTime:0.000011s ]
[ CACHE ] INIT File
[ BEHAVIOR ] Run \addons\briefurl\Briefurl @app_init [ RunTime:0.001333s ]
[ BEHAVIOR ] Run \addons\fastflow\Fastflow @app_init [ RunTime:0.000025s ]
[ BEHAVIOR ] Run \addons\notice\Notice @app_init [ RunTime:0.000272s ]
[ BEHAVIOR ] Run \addons\qrcode\Qrcode @app_init [ RunTime:0.000188s ]
[ BEHAVIOR ] Run \addons\treaty\Treaty @app_init [ RunTime:0.000029s ]
[ BEHAVIOR ] Run \addons\upyun\Upyun @app_init [ RunTime:0.000016s ]
[ BEHAVIOR ] Run Closure @app_init [ RunTime:0.000032s ]
[ BEHAVIOR ] Run app\common\behavior\Common @app_init [ RunTime:0.000250s ]
[ LANG ] /www/wwwroot/open.juabc.com/thinkphp/lang/zh-cn.php
[ BEHAVIOR ] Run app\common\behavior\Common @app_dispatch [ RunTime:0.000013s ]
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[ PARAM ] array ( 'ids' => '4405', )
[ LANG ] /www/wwwroot/open.juabc.com/public/../application/index/lang/zh-cn.php
[ BEHAVIOR ] Run app\common\behavior\Common @module_init [ RunTime:0.000685s ]
[ BEHAVIOR ] Run \addons\upyun\Upyun @module_init [ RunTime:0.000114s ]
[ BEHAVIOR ] Run \addons\wxfollowlogin\Wxfollowlogin @module_init [ RunTime:0.000018s ]
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[ BEHAVIOR ] Run \addons\notice\Notice @config_init [ RunTime:0.000022s ]
[ DB ] INIT mysql
[ BEHAVIOR ] Run \addons\csmtable\Csmtable @action_begin [ RunTime:0.000034s ]
[ RUN ] app\index\controller\Results->views[ /www/wwwroot/open.juabc.com/application/index/controller/Results.php ]
[ VIEW ] /www/wwwroot/open.juabc.com/public/../application/index/view/results/views.html [ array ( 0 => 'user', 1 => 'site', 2 => 'config', 3 => 'data', 4 => 'active', 5 => 'login', 6 => 'catelist', 7 => 'views', ) ]
[ BEHAVIOR ] Run \addons\wxfollowlogin\Wxfollowlogin @view_filter [ RunTime:0.000040s ]

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